Haematopoiesis & Immunity in Drosophila

Presentation

We have a long-standing interest in understanding hematopoiesis using Drosophila melanogaster as a model system. By combining multidisciplinary and integrated approaches encompassing Development, Genetics, Cell Biology and Molecular Biology, we aim at elucidating how blood cell development/formation is orchestrated and modulated under normal and pathological situations. Particularly, we aim at understanding how homeostatic blood cell production is regulated under normal conditions and in response to an immune stress. This includes determining how blood cell fates are specified, which mechanisms control the blood cell progenitor population maintenance versus defferentiation, the dialogues between micro-environment/niche cells and these progenitors, and how an emergency hematopoiesis is induced in response to parasite infestations in order to develop an adapted cellular immune response.

Keywords : Hematopoiesis, microenvironment/niche, lymph gland, stem-progenitor cells, blood cells, cardiac/vascular cells, Drosophila, signaling pathways, regulatory networks, cell plasticity.

Publications

• Douaa Moussalem, Benoit Augé, Luisa Di Stefano, Dani Osman, Vanessa Gobert and Marc Haenlin1.
  Two Isoforms of serpent Containing Either One or Two GATA Zinc Fingers Provide Functional Diversity During Drosophila Development
  Frontiers in Cell and Developmental Biology
  2022 Feb
• Morin-Poulard* I., Destalminil-Letourneau M., Bataille L., Frendo J.L., Lebreton G., Vanzo N. and Michèle Crozatier* .
  Identification of bi-potential blood cell/nephrocyte progenitors in Drosophila: another route for generating blood progenitors.
  Front. Cell Dev. Biol.,
  2022 Feb
• Morin-Poulard I, Tian Y, Vanzo N, Crozatier M..
  Drosophila as a Model to Study Cellular Communication Between the Hematopoietic Niche and Blood Progenitors Under Homeostatic Conditions and in Response to an Immune Stress.
  Front Immunol Aug 16;12:719349. doi: 10.3389/fimmu.2021.719349.
  2021 Aug
• Destalminil-Letourneau M, Morin-Poulard I, Tian Y, Vanzo N, Crozatier M.
  The vascular niche controls Drosophila hematopoiesis via fibroblast growth factor signaling
  Elife
  2021 Jan 4;10:e64672. doi: 10.7554/eLife.64672. PMID: 33395389
• Alexandre Carayon, Laetitia Bataillé, Gaëlle Lebreton, Laurence Dubois, Aurore Pelletier, Yannick Carrier, Antoine Wystrach, Alain Vincent, Jean-Louis Frendo.
  Intrinsic control of muscle attachment sites matching
  eLife
  2020 Jul 2020 Jul 24;9:e57547

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Funding