Stem cells and development (STADE)

Presentation

Coordinators : Alice Davy – Cédric Polesello

The STADE (STem cell And DEvelopment) research programme aims to understand the fundamental processes by which cells acquire the right fate and location to form functional organs and organism.

The two common broad and intersecting scientific questions that are presently addressed in the program are:

1. Which mechanisms maintain stem/progenitor/germ cells or, conversely, drive them to a specific differentiated state?
2. How do tissues/organs acquire their shape and patterns during development?

These questions are studied from different angles and viewpoints: intrinsic (genetics, epigenetics), extrinsic (environmental, systemic, mechanics), at different scales (molecules, cells, organoids, tissues), using a large panel of animal models (Drosophila, zebrafish, Xenopus, mouse, birds) or in vitro models (primary cells, tissue explants).