Cell-cell communication in the mammalian nervous system

Presentation

Research in the team focuses on elucidating mechanisms that govern development of the nervous system and how genetic alterations of this complex developmental program may lead to brain disease in the adult. 
We investigate cell-to-cell communication via the Eph/ephrin signaling pathway, mostly in the context of neurogenesis and neural progenitor specification and maintenance. Our studies combine in vivo experimentations on genetic mouse models, ex vivo experimentations on tissue explants and in vitro cultures of primary neural progenitors, brain tumor stem cells and cell lines.  

Projets

Astrocyte diversity in the brain

Calcium signaling

Exploring parallels between neural progenitors and brain tumor stem cells

Investigating specification of neural progenitor fates

Publications

• Roussat M, Jungas T, Audouard C, Omerani S, Medevielle F, Agius E, Davy A, Pituello F and Bel-Vialar S..
  Control of G2 Phase duration by CDC25B modulates the switch from direct to indirect neurogenesis in the neocortex.
  Journal of Neuroscience
  2023 Feb
• Badouel C., Audouard C. and Davy A. .
  Heterogeneity in the size of the apical surface of cortical progenitors
  Developmental Dynamics
  2022 Oct
• Ohayon D, Aguirrebengoa M, Escalas N, Jungas T, Soula C .
  Transcriptome profiling of the Olig2-expressing astrocyte subtype reveals their unique molecular signature.
  iScience
  2021 Jul
• Defourny J, Audouard C, Davy A, Thiry M..
  Efnb2 haploinsufficiency induces early gap junction plaque disassembly and endocytosis in the cochlea
  Brain Res Bull.
  2021 Jun
• Fawal MA, Jungas T and Davy A.
  Inhibition of DHFR targets the self-renewing potential of brain tumor initiating cells
  Cancer Letters
  2021 Mar

View all publications

Funding

       

Alumni

LECLERC Catherine (CR 2017- 2022)

BADOUEL Caroline (postdoc 2017-2021)

FAWAL Mohamad (postdoc 2015-2021)> project leader Synaxis

KISCHEL Anthony (PhD 2015-2019)> postdoc Sieć Badawcza Łukasiewicz, Wrocław, Poland

LAUSSU Julien (PhD 2011-2015)> postdoc CRBM, Institut Clément Ader, Toulouse, France

ARVANITIS Constandina (postdoc 2007-2010, CR1 2010-2014)

LUXEY Maëva (PhD 2007-2011)> Project Leader, Basel University, Switzerland

BEHAR Annie, AI (CDD 2008-2010)