Publications
Publications de l'équipe Di Stefano/Mattout
- Luisa Di Stefano.
All is quiet on the TE front? The role of chromatin in transposable element silencing.
Cells
2022 Aug Review - Douaa Moussalem, Benoit Augé, Luisa Di Stefano, Dani Osman, Vanessa Gobert and Marc Haenlin1.
Two Isoforms of serpent Containing Either One or Two GATA Zinc Fingers Provide Functional Diversity During Drosophila Development
Frontiers in Cell and Developmental Biology
2022 Feb - Mattout A, Gaidatzis D, Padeken J, Schmid CD, Aeschimann F, Kalck V, Gasser SM. .
LSM2-8 and XRN-2 contribute to the silencing of H3K27me3-marked genes through targeted RNA decay.
Nat Cell Biol.
2020 May To understand this work in 5 minutes, look at the presentation. http://sciversal.com/Home/MinipubPlayer/?slideId=1072 - Harr JC, Schmid CD, Muñoz-Jiménez C, Romero-Bueno R, Kalck V, Gonzalez-Sandoval A, Hauer MH, Padeken J, Askjaer P, Mattout A*, Gasser SM..
Loss of an H3K9me anchor rescues laminopathy-linked changes in nuclear organization and muscle function in an Emery-Dreifuss muscular dystrophy model
Genes Dev.
2020 Apr doi: 10.1101/gad.332213.119 *Corresponding Author - Mattout A, Gaidatzis D, Kalck V, Gasser SM..
A Nuclear RNA Degradation Pathway Helps Silence Polycomb/H3K27me3-Marked Loci in Caenorhabditis elegans.
Cold Spring Harb Symp Quant Biol.
2020 Apr DOI: 10.1101/sqb.2019.84.040238 - Julie M.J. Lepesant, Carole Iampietro, Eugenia Galeota, Benoit Auge, Marion Aguirrenbengoa, Clementine Merce, Camille Chaubet, Vincent Rocher, Marc Haenlin, Lucas Waltzer, Mattia Pelizzola and Luisa Di Stefano.
A dual role of dLsd1 in oogenesis: regulating developmental genes and repressing transposons
Nucleic Acids Research, 2020 Feb 20;48(3):1206-1224
2020 Feb - Altuna M, Urdánoz-Casado A, Sánchez-Ruiz de Gordoa J; Zelaya MV, Labarga A, Lepesant JMJ, Roldán M; Blanco-Luquin I, Perdones A; Larumbe R; Jericó I; Echavarri C; IMéndez-López I; Di Stefano L.; Mendioroz, M..
DNA methylation signature of human hippocampus in Alzheimer’s disease is linked to neurogenesis.
Clinical Epigenetics 2019 Jun 19;11(1):91.
2019 Jun - Wayne O. Miles, Julie M. J. Lepesant, Jessie Bourdeaux, Manuela Texier, Marc A. Kerenyi, Makoto Nakakido, Ryuji Hamamoto, Stuart H. Orkin, Nicholas J. Dyson, Luisa Di Stefano.
The LSD1 Family of Histone Demethylases and the Pumilio Posttranscriptional Repressor Function in a Complex Regulatory Feedback Loop
Molecular and Cellular Biology
2015 Nov - Mattout A, Cabianca DS, Gasser SM..
Chromatin states and nuclear organization in development--a view from the nuclear lamina.
Genome Biol.
2015 Aug Review doi: 10.1186/s13059-015-0747-5 - Mattout A, Aaronson Y, Sailaja BS, Raghu Ram EV, Harikumar A, Mallm JP, Sim KH, Nissim-Rafinia M, Supper E, Singh PB, Sze SK, Gasser SM, Rippe K, Meshorer E..
Heterochromatin Protein 1β (HP1β) has distinct functions and distinct nuclear distribution in pluripotent versus differentiated cells.
Genome Biol.
2015 Jul doi: 10.1186/s13059-015-0760-8 - Kevin N. Dietz, Luisa Di Stefano, Robert C. Maher, Hui Zhu, Marcy E. Macdonald, James F. Gusella, James A. Walker.
The Drosophila Huntington's disease gene ortholog dhtt influences chromatin regulation during development
Human Molecular Genetics
2015 Jan - Luisa Di Stefano and Nicholas J. Dyson.
The emerging roles for histone demethylases in the modulation of signaling pathways
BioMolecular Concepts
2012 Nov - Mattout A, Biran A, Meshorer E..
Global epigenetic changes during somatic cell reprogramming to iPS cells
J Mol Cell Biol.
2011 Dec Cover - Mattout A, Pike BL, Towbin BD, Bank EM, Gonzalez-Sandoval A, Stadler MB, Meister P, Gruenbaum Y, Gasser SM..
An EDMD mutation in C. elegans lamin blocks muscle-specific gene relocation and compromises muscle integrity.
Curr Biol.
2011 Oct DOI: 10.1016/j.cub.2011.08.030 - Luisa Di Stefano, Nicholas J Dyson.
The complex roles of histone demethylases in vivo
Cell Cycle
2011 Jul - Hezroni H, Tzchori I, Davidi A, Mattout A, Biran A, Nissim-Rafinia M, Westphal H, Meshorer E..
H3K9 histone acetylation predicts pluripotency and reprogramming capacity of ES cells.
Nucleus.
2011 Jul doi: 10.4161/nucl.2.4.16767 - Peter Mulligan 1 , Fajun Yang, Luisa Di Stefano, Jun-Yuan Ji, Jian Ouyang, Joy L Nishikawa, Debra Toiber, Madhura Kulkarni, Qun Wang, S Hani Najafi-Shoushtari, Raul Mostoslavsky, Steven P Gygi, Grace Gill, Nicholas J Dyson, Anders M Näär.
A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development
Molecular Cell
2011 Jun https://doi.org/10.1016/j.molcel.2011.04.020 - Luisa Di Stefano , James A Walker, Giosalba Burgio, Davide F V Corona, Peter Mulligan, Anders M Näär, Nicholas J Dyson.
Functional antagonism between histone H3K4 demethylases in vivo
Genes and Development
2011 Jan doi: 10.1101/gad.1983711 - modENCODE Consortium 1 ; Sushmita Roy, Jason Ernst, Peter V Kharchenko, Pouya Kheradpour, Nicolas Negre, Matthew L Eaton, Jane M Landolin, Christopher A Bristow, Lijia Ma, Michael F Lin, Stefan Washietl, Bradley I Arshinoff, Ferhat Ay, Patrick E Meyer, Nicolas Robine, Nicole L Washington, Luisa Di Stefano, Eugene Berezikov, Christopher D Brown, Rogerio Candeias, Joseph W Carlson, Adrian Carr, Irwin Jungreis, Daniel Marbach, Rachel Sealfon, Michael Y Tolstorukov, Sebastian Will, Artyom A Alekseyenko, Carlo Artieri, Benjamin W Booth, Angela N Brooks, Qi Dai, Carrie A Davis, Michael O Duff, Xin Feng, Andrey A Gorchakov, Tingting Gu, Jorja G Henikoff, Philipp Kapranov, Renhua Li, Heather K MacAlpine, John Malone, Aki Minoda, Jared Nordman, Katsutomo Okamura, Marc Perry, Sara K Powell, Nicole C Riddle, Akiko Sakai, Anastasia Samsonova, Jeremy E Sandler, Yuri B Schwartz, Noa Sher, Rebecca Spokony, David Sturgill, Marijke van Baren, Kenneth H Wan, Li Yang, Charles Yu, Elise Feingold, Peter Good, Mark Guyer, Rebecca Lowdon, Kami Ahmad, Justen Andrews, Bonnie Berger, Steven E Brenner, Michael R Brent, Lucy Cherbas, Sarah C R Elgin, Thomas R Gingeras, Robert Grossman, Roger A Hoskins, Thomas C Kaufman, William Kent, Mitzi I Kuroda, Terry Orr-Weaver, Norbert Perrimon, Vincenzo Pirrotta, James W Posakony, Bing Ren, Steven Russell, Peter Cherbas, Brenton R Graveley, Suzanna Lewis, Gos Micklem, Brian Oliver, Peter J Park, Susan E Celniker, Steven Henikoff, Gary H Karpen, Eric C Lai, David M MacAlpine, Lincoln D Stein, Kevin P White, Manolis Kellis.
Identification of functional elements and regulatory circuits by Drosophila modENCODE
Science
2010 Dec doi: 10.1126/science.1198374 - Mattout A, Meshorer E..
Chromatin plasticity and genome organization in pluripotent embryonic stem cells.
Curr Opin Cell Biol.
2010 Jun Review doi: 10.1016/j.ceb.2010.02.001 - Erick J Morris , Jun-Yuan Ji, Fajun Yang, Luisa Di Stefano, Anabel Herr, Nam-Sung Moon, Eun-Jeong Kwon, Kevin M Haigis, Anders M Näär, Nicholas J Dyson.
E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8
Nature
2008 Sep - Nam-Sung Moon , Luisa Di Stefano, Erick J Morris, Reena Patel, Kristin White, Nicholas J Dyson.
E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage
Plos Genetics
2008 Aug https://doi-org.insb.bib.cnrs.fr/10.1371/journal.pgen.1000153 - Wiesel N*, Mattout A*, Melcer S, Melamed-Book N, Herrmann H, Medalia O, Aebi U, Gruenbaum Y..
Laminopathic mutations interfere with the assembly, localization, and dynamics of nuclear lamins
Proc Natl Acad Sci U S A
2008 Jan * Equal Contribution doi: 10.1073/pnas.0708974105 - Luisa Di Stefano , Jun-Yuan Ji, Nam-Sung Moon, Anabel Herr, Nicholas Dyson.
Mutation of Drosophila Lsd1 disrupts H3-K4 methylation, resulting in tissue-specific defects during development
Current Biology
2007 May DOI: 10.1016/j.cub.2007.03.068 - Huan Qiao* , Luisa Di Stefano*, Chan Tian, Yun-Yan Li, Yan-Hui Yin, Xiao-Ping Qian, Xue-Wen Pang, Yan Li, Michael Allen McNutt, Kristian Helin, Yu Zhang, Wei-Feng Chen.
Human TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F
Journal of Biological Chemistry
2007 Jan * Equal contribution - Mattout A, Goldberg M, Tzur Y, Margalit A, Gruenbaum Y..
Specific and conserved sequences in D. melanogaster and C. elegans lamins and histone H2A mediate the attachment of lamins to chromosomes
J Cell Sci.
2007 Jan doi: 10.1242/jcs.03325 - 2006 Oct Moon NS, Di Stefano L, and Dyson N. A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis. Mol Cell Biol. 2006 Oct; 26(20):7601-15.
- Mattout A, Dechat T, Adam SA, Goldman RD, Gruenbaum Y..
Nuclear lamins, diseases and aging.
Curr Opin Cell Biol.
2006 Jun doi: 10.1016/j.ceb.2006.03.007 - Haithcock E, Dayani Y, Neufeld E, Zahand AJ, Feinstein N, Mattout A, Gruenbaum Y, Liu J..
Age-related changes of nuclear architecture in Caenorhabditis elegans.
Proc Natl Acad Sci USA
2005 Nov doi: 10.1073/pnas.0506955102 - 2005 Oct Moon NS, Frolov MV, Kwon EJ, Di Stefano L, Dimova DK, Morris E, Taylor-Harding B, White K and Dyson N. Drosophila E2F1 has context specific pro and anti- apoptotic properties during development. Developmental Cell. 2005 Oct; 9(4): 463-75.
- Mattout-Drubezki A, Gruenbaum Y.
Dynamic Interactions of Nuclear Lamina Proteins With Chromatin and Transcriptional Machinery
Cell Mol Life Sci
2005 Oct doi: 10.1007/s00018-003-3038-3 - 2005 Sep Christensen J, Cloos P, Toftegaard U, Klinkeberg D, Bracken AP, Trinh E, Heeran M, Di Stefano L and Helin K. Characterization of E2F8, a novel E2F-like cell cycle regulated repressor of E2F-activated transcription. Nucleic Acid Research. 2005 Sep22; 33 (17); 5458-70.
- 2003 Dec Di Stefano L, Jensen M and Helin K. E2F7, a novel E2F featuring DP independent repression of a subset of E2F-regulated genes. The EMBO Journal. 2003 Dec 1;22(23):6289-98.
